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Published on: May 9, 2025
Improvement in cognitive function after surgery for low-grade glioma
Resection of low-grade gliomas (LGGs) significantly improves memory and executive functions, enhancing quality of life. Histopathological markers like GFAP and p53 may also correlate with cognitive improvements in brain tumor patients.
Area of Science:
- Neurosurgery
- Neuro-oncology
- Cognitive Neuroscience
Background:
- Cognition is crucial for health-related quality of life (HRQoL) in brain tumor patients.
- The impact of surgery on cognition and HRQoL after low-grade glioma (LGG) resection is not fully understood.
Purpose of the Study:
- To investigate the effect of LGG resection on cognitive function.
- To explore correlations between cognitive outcomes and histopathological markers.
Main Methods:
- Retrospective analysis of 49 LGG patients with pre- and postoperative neurocognitive evaluations.
- Comprehensive neurocognitive testing assessing memory, language, attention, and executive functions.
- Analysis of tumor characteristics, including histopathological markers (IDH, p53, GFAP).
Main Results:
- Significant postoperative improvements in memory and executive functions were observed.
- Tumor location (dominant vs. nondominant side) influenced cognitive recovery patterns.
- p53 and GFAP positivity showed associations with improved language and memory, respectively.
Conclusions:
- LGG resection offers significant oncological and cognitive benefits, improving functional outcomes.
- Specific histopathological markers may predict cognitive improvements post-surgery.
- Early, aggressive surgical treatment for LGG is supported.
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