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Updated: Feb 12, 2026

Identification and Quantification of Deranged Metabolites in Critically Ill Patients Using NMR-Based Metabolomics
Published on: November 29, 2024
Unambiguous identification and characterization of a long-term human metabolite of dehydrochloromethyltestosterone
Guro Forsdahl1,2, Thomas Geisendorfer1, Lorenz Göschl1
1Doping Control Laboratory, Seibersdorf Labor GmbH, Seibersdorf, Austria.
Abstract:
In doping control analysis, the characterization of urinary steroid metabolites is of high interest for a targeted and long-term detection of prohibited anabolic androgenic steroids (AAS). In this work, the structure of a long-term metabolite of dehydrochloromethyltestosterone (DHCMT) was elucidated. Altogether, 8 possible metabolites with a 17α-methyl-17β-hydroxymethyl - structures were synthesized and compared to a major DHCMT long-term metabolite detected in reference urine excretion samples. The confirmed structure of the metabolite was 4α-chloro-18-nor-17β-hydroxymethyl-17α-methyl-5α-androst-13-en-3α-ol.
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