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Asymmetric Walkway: A Novel Behavioral Assay for Studying Asymmetric Locomotion

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Published on: January 15, 2016

Substrate Directed Asymmetric Reactions.

Sukalyan Bhadra¹, Hisashi Yamamoto²

¹Inorganic Materials and Catalysis Division, Academy of Scientific and Innovative Research , CSIR-Central Salt and Marine Chemicals Research Institute , G. B. Marg , Bhavnagar , 364002 Gujarat , India.

Chemical Reviews

|March 24, 2018

Summary

Substrate-directed synthesis uses directing groups to control asymmetric reactions, offering a powerful method for creating complex chiral molecules. This review highlights recent advances in these stereoselective transformations.

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Area of Science:

Organic Chemistry
Asymmetric Synthesis
Catalysis

Background:

Historically, reagent-controlled reactions dominated asymmetric synthesis.
Current methods increasingly rely on substrate-directed approaches for chiral molecule construction.

Purpose of the Study:

To provide a concise overview of recent substrate-directed asymmetric transformations.
To highlight advances in the last two decades, focusing on common directing groups.

Main Methods:

Review of recent literature on substrate-directed asymmetric reactions.
Focus on reactions utilizing directing groups like hydroxy, amide, and sulfonamide.
Inclusion of examples of chemo-, regio-, and diastereoselective reactions.

Main Results:

Substrate-directed approaches enable high stereoselection through ordered transition states.
These methods are crucial for preparing complex chiral frameworks from simple precursors.
Application in functionalizing enantiopure substrates into single diastereomers.

Conclusions:

Substrate-directed synthesis is an indispensable tool in modern organic chemistry.
Recent advances have expanded the scope and efficiency of these stereoselective reactions.
The review emphasizes the utility of common directing groups in achieving complex molecular architectures.