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Involvement of synaptosomal neurotransmitter amino acids in audiogenic seizure-susceptibility and -severity of Rb mice.

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ADP-ribosylation: approach to molecular basis of aging.

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[ADP ribosylation: knowledge and perspectives].

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    Comptes Rendus Des Seances De La Societe De Biologie Et De Ses Filiales
    |January 1, 1987
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    Summary
    This summary is machine-generated.

    Polyadenosine diphosphate ribose (polyADPR) and its polymerase (polyADPR-P) are vital in eukaryotic cells, impacting DNA processes and gene expression. Inhibiting polyADPR offers potential for antitumor therapy.

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    Area of Science:

    • Biochemistry
    • Molecular Biology
    • Cell Biology

    Context:

    • Polyadenosine diphosphate ribose (polyADPR) and polyADPR-polymerase (polyADPR-P) were discovered in 1966.
    • These enzymes and polymers are present in all eukaryotic cells.
    • Protein ADP-ribosylation is involved in DNA duplication, transcription, and repair.

    Purpose:

    • To explore the role of polyADPR and polyADPR-P in cellular processes.
    • To investigate the function of ADP-ribosylation in nuclear and cytoplasmic contexts.
    • To evaluate the potential of ADP-ribosylation inhibitors in cancer therapy.

    Summary:

    • PolyADPR polymerase synthesizes polyADPR, modifying nuclear proteins to influence DNA processes and enzyme activity.
    • ADP-ribosyl transferases in mitochondria and messenger ribonucleoprotein (mRNP) particles are involved in gene expression.
    • MonoADP-ribosylation enzymes are found in bacterial toxins and animal tissues.
    • Nicotinamide and 3-aminobenzamide inhibit ADP-ribosylation, affecting cell proliferation.

    Impact:

    • ADP-ribosylation is a fundamental cellular process with diverse functions.
    • Understanding ADP-ribosylation mechanisms can reveal new therapeutic targets.
    • Inhibitors of ADP-ribosylation show promise as adjuvant therapies for tumoral growth.