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Updated: Feb 12, 2026

An Immunocompetent Murine Model for Laser Interstitial Thermal Therapy of Glioblastoma
Published on: November 15, 2024
Laser interstitial thermal therapy for an eloquent region supratentorial brain lesion
Mayur Sharma1, Daria Krivosheya2, Hamid Borghei-Razavi2
11Department of Neurosurgery, University of Louisville, Kentucky; and.
Abstract:
Laser interstitial thermal therapy (LITT) is a minimally invasive stereotactic technique that causes tumor ablation using thermal energy. LITT has shown to be efficacious for the treatment of deep-seated brain lesions, including those near eloquent areas. In this video, the authors present the case of a 62-year-old man with a history of metastatic melanoma who presented with worsening right-sided hemiparesis. MRI revealed a contrast-enhancing lesion in left centrum semiovale in close proximity to corticospinal tracts, consistent with radiation necrosis. The authors review their stepwise technique of LITT with special attention to details for a lesion located near eloquent area. The video can be found here: https://youtu.be/ndrTgi6MXqE .
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