Related Experiment Video

Updated: Feb 12, 2026

Transplantation of Tail Skin to Study Allogeneic CD4 T Cell Responses in Mice
06:48

Transplantation of Tail Skin to Study Allogeneic CD4 T Cell Responses in Mice

Published on: July 25, 2014

13.8K

Post-influenzal triazole-resistant aspergillosis following allogeneic stem cell transplantation

Alida Fe Talento1,2, Katie Dunne1, Niamh Murphy2

  • 1Department of Clinical Microbiology, Trinity College Dublin, Dublin 8, Ireland.

Mycoses
|March 24, 2018
PubMed

Insights

Influenza infection increases the risk of invasive pulmonary aspergillosis (IPA). Early diagnosis and surveillance are crucial, especially with emerging antifungal resistance in Aspergillus fumigatus.

Area of Science:

  • Mycology
  • Infectious Diseases
  • Hematology

Background:

  • Influenza virus infection is an emerging risk factor for invasive pulmonary aspergillosis (IPA).
  • Delayed diagnosis of IPA leads to delayed antifungal therapy.
  • Antifungal resistance in Aspergillus fumigatus necessitates early detection strategies.

Observation:

  • Two allogeneic stem cell transplant recipients developed IPA following influenza infection.
  • The IPA cases were caused by triazole-resistant Aspergillus fumigatus.
  • Management of these cases presented significant clinical challenges.

Findings:

  • Influenza infection can predispose immunocompromised patients to invasive pulmonary aspergillosis.
  • Triazole-resistant Aspergillus fumigatus poses a threat in post-influenza settings.
  • Early and accurate diagnosis is critical for effective treatment of IPA.

Implications:

  • Highlights the need for increased vigilance for IPA in influenza patients, particularly transplant recipients.
  • Emphasizes the importance of diagnostic strategies to identify triazole resistance.
  • Underscores the necessity of antifungal surveillance programs to monitor resistance patterns.
Keywords:
influenzainvasive pulmonary aspergillosisstem cell transplanttriazole resistance

More Related Videos

Generation of Multivirus-specific T Cells to Prevent/treat Viral Infections after Allogeneic Hematopoietic Stem Cell Transplant08:52

Generation of Multivirus-specific T Cells to Prevent/treat Viral Infections after Allogeneic Hematopoietic Stem Cell Transplant

Published on: May 27, 2011

17.8K
Isolation and Transplantation of Hematopoietic Stem Cells HSCs20:38

Isolation and Transplantation of Hematopoietic Stem Cells HSCs

Published on: February 25, 2007

24.3K

Related Concept Videos

Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore...
28.1K
Adult Stem Cells01:33

Adult Stem Cells

Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously...
33.9K
Embryonic Stem Cells00:58

Embryonic Stem Cells

Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
32.6K
Embryonic Stem Cells00:57

Embryonic Stem Cells

Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
ES cells are grown in a culture medium where they can divide indefinitely, creating ES cell lines. Under certain conditions, ES cells can differentiate, either spontaneously into a variety of...
5.2K
Resistivity01:22

Resistivity

When a voltage is applied to a conductor, an electrical field is generated, and charges in the conductor feel the force due to the electrical field. The current density that results depends on the electrical field and the properties of the material. In some materials, including metals at a given temperature, the current density is approximately proportional to the electrical field. In these cases, the current density can be modeled as:
4.6K
Resistance01:19

Resistance

When a current moves through any conductor, the conductor causes some level of difficulty for the current to flow. The measure of that difficulty is known as the resistance of the material and is represented by R. Every material has its own resistance. In the case of conductors, heat is emitted whenever a current passes through them. Resistance depends on the resistivity of the material. Resistivity is a characteristic of the material used to fabricate electrical components, whereas the...
6.1K