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Related Experiment Video

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Systemic and Local Drug Delivery for Treating Diseases of the Central Nervous System in Rodent Models

Systemic and Local Drug Delivery for Treating Diseases of the Central Nervous System in Rodent Models

Published on: August 16, 2010

Nucleoside-Based Self-Assembling Drugs for Localized Drug Delivery.

Katherine J Skilling¹, Michael J Stocks¹, Barrie Kellam¹

¹School of Pharmacy, University of Nottingham, Nottingham, NG7 2RD, UK.

|March 24, 2018

Summary

Researchers developed novel gelators using gemcitabine and lamivudine nucleoside analogues for potential localized drug delivery. These nucleoside-based gelators show promise for new cancer treatments and therapies.

Keywords:

drug delivery gels gemcitabine lamivudine nucleosides

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Last Updated: Feb 12, 2026

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Published on: August 16, 2010

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Published on: October 4, 2013

Area of Science:

Medicinal Chemistry
Materials Science
Drug Delivery

Background:

Nucleoside analogues are crucial in various therapeutic applications.
Developing effective localized drug delivery systems remains a significant challenge in medicine.
Self-assembling small molecules offer potential for advanced drug formulations.

Purpose of the Study:

To synthesize and characterize novel gelators based on nucleoside analogues.
To evaluate the therapeutic potential of these nucleoside-based gelators.
To explore their application in localized drug delivery systems.

Main Methods:

Synthesis of gemcitabine and lamivudine derivatives.
Rheological analysis to determine gel properties.
Transmission electron microscopy (TEM) for structural characterization.
In vitro growth inhibition assays for cytotoxicity assessment.

Main Results:

Successful synthesis of a series of nucleoside-based gelators.
Rheological studies confirmed the formation of stable gel networks.
TEM revealed the self-assembled fibrillar structures of the gels.
Gemcitabine derivatives demonstrated significant growth inhibition of cancer cells.

Conclusions:

Nucleoside analogues can be effectively formulated into self-assembling hydrogels.
These novel gelators show potential as carriers for localized drug delivery.
Gemcitabine-based gels represent a promising strategy for novel cancer therapeutics.