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H2S to Mitigate Vascular Aging: A SIRT1 Connection
Thiruma V Arumugam1, Brian K Kennedy2
1Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, MD9, 2 Medical Drive, Singapore 117593, Singapore; School of Pharmacy, Sungkyunkwan University, Suwon 16419, Republic of Korea.
Cell
|March 24, 2018
Summary
Hydrogen sulfide (H2S) acts as a vital gasotransmitter in the body. New research shows H2S enhances SIRT1-dependent blood vessel growth, particularly when amino acids are scarce.
Area of Science:
- Physiology
- Biochemistry
- Molecular Biology
Background:
- Hydrogen sulfide (H2S) is recognized as an endogenous gasotransmitter with significant physiological roles.
- Understanding the regulatory mechanisms of H2S in biological processes is crucial for therapeutic development.
Purpose of the Study:
- To investigate the role of H2S in SIRT1-dependent angiogenesis.
- To explore the triggers for H2S-mediated angiogenesis, specifically amino acid deprivation.
Main Methods:
- The study by Das et al. examined the augmentation of SIRT1-dependent angiogenesis by H2S.
- The study by Longchamp et al. investigated the initiation of H2S-dependent angiogenesis under conditions of amino acid deprivation.
Main Results:
- H2S was found to augment angiogenesis in a SIRT1-dependent manner.
- Amino acid deprivation was identified as a trigger for H2S-dependent angiogenesis.
Conclusions:
- H2S plays a key role in promoting blood vessel formation through SIRT1 signaling.
- Nutritional cues, such as amino acid scarcity, can activate H2S pathways to stimulate angiogenesis.
