Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Understanding the Self01:28

Understanding the Self

324
The self is a central aspect of human identity, encompassing an individual’s beliefs, emotions, perceptions, and experiences. It is a cognitive and psychological construct that enables individuals to interpret their traits and behaviors, influencing how they perceive themselves and interact with the world. While personality consists of stable and enduring characteristics, the self is shaped by self-perception and social experiences. This distinction highlights the dynamic nature of the...
324
Proteomics01:33

Proteomics

9.9K
A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...
9.9K
Understanding Self-Concept01:20

Understanding Self-Concept

312
The self-concept encompasses individuals' beliefs about themselves, structured through cognitive frameworks known as self-schemas. These schemas function as mental representations of specific traits or behaviors, influencing how self-relevant information is perceived, processed, and remembered. For example, individuals who are schematic for body weight are more likely to interpret routine experiences—such as dining out or shopping—through the lens of that trait. Conversely, those...
312
Understanding Deception01:14

Understanding Deception

175
Deception is a pervasive aspect of human communication. Empirical studies have shown that most individuals engage in some form of deceit on a daily basis, with approximately 20% of social exchanges involving deceptive elements. Lying follows a developmental trajectory, peaking during adolescence and declining with age, possibly due to the maturation of cognitive control and social accountability.Cognitive and Social Factors in Deception DetectionDespite its prevalence, accurately detecting...
175
Understanding Love01:27

Understanding Love

195
Love, as a multifaceted psychological construct, encompasses emotions, cognitive processes, and behavioral patterns that play a crucial role in human relationships. It extends beyond attraction, manifesting in deep, enduring connections that influence personal well-being and social structures.Psychological Dimensions of LoveLove differs from friendship and mere liking through its depth and intensity. While friendship is built on mutual respect, trust, and companionship, love involves emotional...
195
Understanding Consciousness01:23

Understanding Consciousness

2.2K
Consciousness can be defined as the state of being aware of and able to think about one's existence, sensations, and surroundings. It encompasses two major components: awareness and arousal. Awareness pertains to the recognition of environmental stimuli and internal states. At the same time, arousal refers to the physiological readiness to engage with these stimuli, which varies significantly between states like sleep and wakefulness.
Sleep, a crucial state, is characterized by reduced...
2.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Elastic scaffolds reinforced stem cell-laden collagen-derived hybrid hydrogels to engineer 3D anisotropic cellular microenvironment.

Materials today. Bio·2026
Same author

Adding beta-tricalcium phosphate ceramic to additive manufactured 3D porous Ti6Al4V scaffolds enhances osteogenic activity of human mesenchymal stromal cells in vitro.

Biomaterials advances·2026
Same author

Additive manufacturing and in vitro characterization of scaffolds consisting of PCL/P<sub>2</sub>O<sub>5</sub>-free bioactive glasses composites with angiogenic and osteogenic potential.

Biomaterials·2026
Same author

Micro-cold-forming: a simple, rapid, and inexpensive method for the fabrication of microcavities for 3D cell culture.

RSC advances·2026
Same author

Dual-Responsive Hydrogels Engineer Anisotropic Cellular Microenvironment to Modulate Stem Cell Organization and Fate.

Small (Weinheim an der Bergstrasse, Germany)·2026
Same author

Multicellular microtissues from fused ligament- and bone-cell spheroids relevant to enthesis repair.

Materials today. Bio·2026

Related Experiment Video

Updated: Feb 12, 2026

Biological Compatibility Profile on Biomaterials for Bone Regeneration
10:28

Biological Compatibility Profile on Biomaterials for Bone Regeneration

Published on: November 16, 2018

13.4K

Understanding interactions between biomaterials and biological systems using proteomics.

Ziryan Othman1, Berta Cillero Pastor2, Sabine van Rijt1

  • 1MERLN Institute for Technology-Inspired Regenerative Medicine, Department of Instructive Biomaterials Engineering, Maastricht University, Universiteitssingel 40, 6229 ER Maastricht, The Netherlands.

Biomaterials
|March 24, 2018
PubMed
Summary
This summary is machine-generated.

Biomaterials in regenerative medicine interact with the body through proteins. Understanding these protein interactions, particularly via proteomics, is key to designing advanced biomaterials for tissue repair and regeneration.

Keywords:
BiomaterialsHigh-content screeningMass spectrometryProteinsRegenerative medicine

More Related Videos

The Use of Chemostats in Microbial Systems Biology
13:19

The Use of Chemostats in Microbial Systems Biology

Published on: October 14, 2013

31.8K
Label-Free Quantitative Proteomics Workflow for Discovery-Driven Host-Pathogen Interactions
05:37

Label-Free Quantitative Proteomics Workflow for Discovery-Driven Host-Pathogen Interactions

Published on: October 20, 2020

7.5K

Related Experiment Videos

Last Updated: Feb 12, 2026

Biological Compatibility Profile on Biomaterials for Bone Regeneration
10:28

Biological Compatibility Profile on Biomaterials for Bone Regeneration

Published on: November 16, 2018

13.4K
The Use of Chemostats in Microbial Systems Biology
13:19

The Use of Chemostats in Microbial Systems Biology

Published on: October 14, 2013

31.8K
Label-Free Quantitative Proteomics Workflow for Discovery-Driven Host-Pathogen Interactions
05:37

Label-Free Quantitative Proteomics Workflow for Discovery-Driven Host-Pathogen Interactions

Published on: October 20, 2020

7.5K

Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Proteomics

Background:

  • The role of biomaterials is shifting from passive function replacement to actively promoting in situ tissue regeneration and subsequent degradation.
  • Understanding biomaterial-host interactions over time and space is crucial for developing advanced biomaterials with enhanced functionalities like biocompatibility and bioactivity.
  • Proteins are central to biomaterial-cell and biomaterial-tissue interactions, with initial protein adsorption significantly influencing cellular responses such as growth and differentiation.

Purpose of the Study:

  • To review the current knowledge on the role of proteins in cell-biomaterial and tissue-biomaterial interactions.
  • To highlight the contributions of proteomics, primarily mass spectrometry-based techniques, in advancing this understanding.
  • To discuss the application of these insights in biomaterial design for regenerative medicine.

Main Methods:

  • Focus on proteomics studies, predominantly utilizing mass spectrometry.
  • Analysis of protein adsorption onto biomaterial surfaces.
  • Evaluation of protein production by cells cultured on biomaterials and analysis of extracellular matrices and their products.
  • Exploration of nanoparticle-based biomaterials' safety and efficacy.

Main Results:

  • Proteomics has elucidated the critical role of protein adsorption in mediating initial biomaterial interactions.
  • Insights into protein production by cells and the composition of extracellular matrices provide a deeper understanding of regenerative processes.
  • Mass spectrometry techniques have been instrumental in characterizing these complex biological responses to biomaterials.

Conclusions:

  • Proteomics offers valuable insights into biomaterial-host interactions, crucial for regenerative medicine.
  • Further development and application of mass spectrometry techniques, including mass spectrometry imaging, will enhance the spatial and molecular understanding of these interactions.
  • This knowledge facilitates the rational design of next-generation biomaterials for improved clinical outcomes.