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Updated: Feb 12, 2026

Orthotopic Transplantation of Syngeneic Lung Adenocarcinoma Cells to Study PD-L1 Expression
Published on: January 19, 2019
Graft-Versus-Tumor Effect in Adenocarcinoma of the Lung
Daniel C Wiener1, Carlos E Bravo-Iñiguez1, Vincent Trien-Vihn Ho2
1Division of Thoracic Surgery, Brigham and Women's Hospital, Boston, Massachusetts.
Abstract:
Donor T cells after allogeneic hematopoietic cell transplantation can give rise to the graft-versus-tumor (GVT) effect in hematologic malignancies. GVT effect has been reported previously to cause regression of some solid tumors. However, none have reported a documented case of GVT effect leading to complete resolution of adenocarcinoma of the lung. Here, we present the case of complete regression of a pathologically proven adenocarcinoma of the lung in a patient undergoing myeloablative-matched unrelated donor peripheral blood stem cell transplantation for the treatment of acute myelogenous leukemia.
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