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C-reactive protein response patterns after antibiotic treatment among children with scalds

Ingrid Steinvall1, Matilda Karlsson1, Moustafa Elmasry2

  • 1Department of Hand Surgery, Plastic Surgery, and Burns, Linköping University, Linköping, Sweden; Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden.

Burns : Journal of the International Society for Burn Injuries
|March 25, 2018
PubMed

Insights

Antibiotic treatment in scalded children leads to a higher initial C-reactive protein (CRP) increase but a faster decrease in CRP levels within two weeks. This indicates a more rapid inflammatory resolution in treated patients.

Area of Science:

  • Pediatric Burn Care
  • Inflammatory Response Markers
  • Antibiotic Efficacy

Background:

  • Scalds are the most frequent burn injury in children.
  • Limited data exists on the inflammatory response following pediatric scalds.
  • Understanding inflammation is crucial for effective treatment.

Purpose of the Study:

  • To investigate the inflammatory response in scalded children treated with antibiotics.
  • To analyze C-reactive protein (CRP), procalcitonin (PCT), and white blood cell count (WCC) trends.
  • To assess the impact of antibiotic therapy on inflammatory markers.

Main Methods:

  • Retrospective study of 216 children with scalds (2010-2016).
  • Recorded CRP, PCT, and WCC measurements within 14 days post-injury.
  • Utilized multivariable regression for panel data analysis of inflammatory response.

Main Results:

  • Children receiving antibiotics showed a 45 mg/L higher CRP level (p<0.001).
  • CRP decreased more than twice as fast (8.8 mg/L per day) in the antibiotic-treated group.
  • This suggests a more rapid resolution of inflammation with antibiotic use.

Conclusions:

  • Antibiotic treatment in pediatric scalds is associated with an initial rise in CRP.
  • CRP levels in treated children rapidly subside during the second week post-injury.
  • Findings highlight the dynamic inflammatory response to antibiotic therapy in scalded children.
Abstract

Keywords:
AntibioticsBurnsC-reactive proteinInflammatory responseProcalcitoninWhite blood cell count

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