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Updated: Feb 12, 2026

Measurements of Motor Function and Other Clinical Outcome Parameters in Ambulant Children with Duchenne Muscular Dystrophy
09:18

Measurements of Motor Function and Other Clinical Outcome Parameters in Ambulant Children with Duchenne Muscular Dystrophy

Published on: January 12, 2019

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Bilateral Cerebral Infarctions and Intracardiac Thrombus in a Young Duchenne Muscular Dystrophy Patient

Yanan Qiao1, Manabu Inoue2, Muneaki Kikuno2

  • 1Department of Neurology, China-Japan Friendship Hospital, Beijing China.

Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association
|March 25, 2018
PubMed

Insights

Duchenne muscular dystrophy patients experiencing cerebral infarctions may benefit from warfarin therapy. This anticoagulant medication helped resolve cerebral artery occlusion and left ventricular thrombus in a young man.

Area of Science:

  • Neurology
  • Cardiology
  • Genetics

Background:

  • Duchenne muscular dystrophy (DMD) is a severe genetic disorder characterized by progressive muscle degeneration.
  • Cerebrovascular events, including cerebral infarction, are rare but serious complications in DMD patients.
  • The management of thromboembolic events in DMD requires careful consideration due to potential complications.

Observation:

  • A 31-year-old male patient diagnosed with Duchenne muscular dystrophy presented with bilateral cerebral hemisphere infarctions.
  • The patient also exhibited occlusion of the right middle cerebral artery.
  • A thrombus was detected in the left ventricle.

Findings:

  • Spontaneous recanalization of the right middle cerebral artery occurred on the day following admission.
  • Warfarin therapy was initiated for the patient.
  • The left ventricular thrombus resolved completely by the eighth day of warfarin treatment.

Implications:

  • This case suggests that warfarin may be an effective treatment for thromboembolic complications in Duchenne muscular dystrophy patients.
  • Further research is warranted to explore the safety and efficacy of anticoagulation in this specific patient population.
  • Understanding the mechanisms behind cerebrovascular events in DMD could lead to improved preventative strategies.

Keywords:
Duchenne muscular dystrophyanticoagulationejection fractionstrokethrombus

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