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Related Experiment Video

Updated: Feb 12, 2026

Fetal Echocardiography and Pulsed-wave Doppler Ultrasound in a Rabbit Model of Intrauterine Growth Restriction
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Universal screening for foetal growth restriction.

Gordon C S Smith1

  • 1Department of Obstetrics and Gynaecology, University of Cambridge, NIHR Cambridge Comprehensive Biomedical Research Centre, Cambridge, UK.

Best Practice & Research. Clinical Obstetrics & Gynaecology
|March 25, 2018
PubMed
Summary

Identifying foetal growth restriction (FGR) requires better clinical methods. Current screening lacks accuracy, necessitating research into more sensitive and specific tests to improve pregnancy outcomes and reduce mortality.

Keywords:
BiomarkerDopplerFoetal growth restrictionPlacentaScreeningUltrasound

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Area of Science:

  • Obstetrics and Gynecology
  • Perinatal Medicine
  • Clinical Diagnostics

Background:

  • Foetal growth restriction (FGR) significantly contributes to pregnancy morbidity and mortality.
  • Current clinical methods for FGR detection, including risk assessment and ultrasound, exhibit poor performance.
  • Universal ultrasound screening has not improved outcomes and can lead to adverse effects like iatrogenic prematurity.

Purpose of the Study:

  • To highlight the limitations of current FGR screening methods.
  • To emphasize the need for developing more sensitive and specific diagnostic tests for FGR.
  • To guide future research and clinical trial design for FGR screening and intervention.

Main Methods:

  • Review of current clinical assessment and ultrasound screening practices for FGR.
  • Discussion of research focusing on novel screening approaches, such as combining ultrasound with placental biomarkers.
  • Emphasis on the necessity of high-quality diagnostic accuracy studies, including blinding of results.

Main Results:

  • Existing clinical FGR identification methods are inadequate.
  • Universal ultrasound screening may negatively impact outcomes due to false positives and iatrogenic prematurity.
  • Development of improved screening tests is an active area of research.

Conclusions:

  • There is a critical need for improved diagnostic accuracy in identifying FGR.
  • Future research should focus on developing and validating novel screening tools.
  • Careful planning and large sample sizes are essential for future FGR screening and intervention trials to accurately assess perinatal outcomes.