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Proteus mirabilis harboring carbapenemase NDM-5 and ESBL VEB-6 detected in Austria

Thomas Valentin1, Gebhard Feierl2, Lilian Masoud-Landgraf2

  • 1Section of Infectious Diseases and Tropical Medicine, Department of Internal Medicine, Medical University of Graz, Austria.

Diagnostic Microbiology and Infectious Disease
|March 25, 2018
PubMed

Insights

This study reports carbapenemase-producing Proteus mirabilis with NDM-5 in Austria. The findings highlight the spread of diverse beta-lactamases, including OXA-181 and VEB-6, in clinical isolates.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Antimicrobial Resistance

Background:

  • The increasing prevalence of carbapenemase-producing Enterobacteriaceae (CPE) poses a significant global health threat.
  • Understanding the emergence and dissemination of novel resistance mechanisms is crucial for effective infection control.

Observation:

  • A case of carbapenemase-harboring Proteus mirabilis was identified in Austria.
  • This isolate harbored the New Delhi metallo-beta-lactamase 5 (NDM-5) gene.
  • Other bacterial strains with various beta-lactamases, including OXA-181 and VEB-6, were also detected.

Findings:

  • The Proteus mirabilis isolate was obtained from a subphrenic abscess.
  • The patient had a history of broad-spectrum antibiotic treatment in Bangladesh prior to the Austrian diagnosis.
  • Co-existence of multiple beta-lactamase types (NDM-5, OXA-181, VEB-6) in clinical isolates indicates complex resistance patterns.

Implications:

  • This case underscores the potential for international travel and prior antibiotic exposure to facilitate the spread of multidrug-resistant organisms.
  • The presence of NDM-5 in Proteus mirabilis in Austria warrants enhanced surveillance and infection control measures.
  • Further research is needed to understand the epidemiology and clinical impact of these diverse beta-lactamases.
Keywords:
Antimicrobial resistanceCarbapenem-resistant EnterobacteriaceaeEscherichia coliKPC-2Klebsiella pneumoniaeOXA-181

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