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Published on: June 23, 2023
Beta oscillations and urinary voiding in Parkinson disease
Holly A Roy1, Tipu Z Aziz2, James J Fitzgerald2
1From the Department of Functional Neurosurgery (H.A.R., T.Z.A., J.J.F., A.L.G.) and Nuffield Department of Surgical Sciences (H.A.R., T.Z.A., J.J.F., A.L.G.), John Radcliffe Hospital, Oxford; and Department of Neurosurgery (H.A.R.), Derriford Hospital, Plymouth, UK. roy.hollyann@gmail.com.
Beta oscillations in the globus pallidus interna (GPi) are involved in urinary voiding in Parkinson disease (PD). GPi beta signals correlate with lower urinary tract symptoms, suggesting a role in PD pathophysiology.
Area of Science:
- Neuroscience
- Urology
- Movement Disorders
Background:
- Parkinson disease (PD) is associated with lower urinary tract symptoms (LUTS).
- The neural mechanisms underlying voiding dysfunction in PD are not fully understood.
Purpose of the Study:
- To investigate the role of beta oscillations in urinary voiding.
- To explore the association between beta oscillations and LUTS in PD patients.
Main Methods:
- Local field potentials were recorded from the subthalamic nucleus (STN) and globus pallidus interna (GPi) during voiding in PD patients.
- Beta oscillatory power was correlated with LUTS assessed by the International Consultation on Incontinence Questionnaire.
Main Results:
- Beta suppression was observed during voiding in the GPi, but not the STN.
- GPi beta signals during voiding significantly correlated with incontinence severity and urinary frequency.
Conclusions:
- The GPi is implicated in urinary voiding, with mechanisms linked to beta frequency band signals.
- Beta oscillations may play a broader role in the pathophysiology of LUTS in PD.
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