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Updated: Feb 12, 2026

Genome-Wide Analysis of DNA Methylation in Gastrointestinal Cancer
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Genome-Wide Analysis of DNA Methylation in Gastrointestinal Cancer

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Molecular genomic landscapes of hepatobiliary cancer

Tatsuhiro Shibata1,2, Yasuhito Arai2, Yasushi Totoki2

  • 1Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, University of Tokyo, Tokyo, Japan.

Cancer Science
|March 25, 2018
PubMed

Insights

This study reveals key genetic drivers for hepatocellular carcinoma (HCC) and biliary tract cancer, identifying molecular targets for improved diagnosis and treatment of these prevalent East Asian cancers.

Area of Science:

  • Oncology
  • Genomics
  • Molecular Biology

Background:

  • Hepatocellular carcinoma (HCC) and biliary tract cancer are more prevalent in East Asia than in Western countries.
  • Understanding the molecular drivers of these cancers is crucial for developing targeted therapies.

Purpose of the Study:

  • To comprehensively analyze the genomic landscape of HCC and biliary tract cancer.
  • To identify core driver genes and molecular alterations.
  • To discover potential therapeutic targets and molecular classifications.

Main Methods:

  • Analysis of 1340 multi-ethnic HCC genomes.
  • Genomic profiling of biliary tract cancer genomes.
  • Integrative multi-omics data analysis.

Main Results:

  • Identified three core drivers (TP53, TERT, WNT signaling) for HCC.
  • Identified five core drivers (TP53, ARID1A, KRAS, SMAD4, BAP1) and specific alterations for biliary tract cancer.
  • Discovered complex mutational signatures and identified molecular classifications linked to clinical outcomes and therapeutic targets, including immune checkpoint molecules.

Conclusions:

  • The genomic landscape of HCC and biliary tract cancer is complex and influenced by epidemiological factors.
  • Molecular classifications correlate with clinical outcomes and suggest potential therapeutic strategies.
  • Further research and international collaboration are essential for advancing precise treatments, diagnosis, and prevention.

Keywords:
biliary tract cancerdriver genehepatocellular carcinomamolecular classificationmutational signature

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