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[Lymphokines, interleukins, cytokines: function and action].

S H Kaufmann

    Immunitat Und Infektion
    |July 1, 1987
    PubMed
    Summary
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    This review summarizes key lymphokines and monokines, detailing their roles in immune responses. It explores interleukin functions in T-lymphocyte generation and proposes new definitions based on structure and function.

    Area of Science:

    • Immunology
    • Cellular Biology
    • Molecular Biology

    Context:

    • The immune system relies on complex cell-to-cell communication.
    • Lymphokines and monokines are critical signaling molecules in immune responses.
    • Understanding these mediators is key to deciphering immune mechanisms.

    Purpose:

    • To review major lymphokines and monokines and their biological roles.
    • To discuss the interplay between antigens and interleukins in immune cell generation.
    • To present mechanisms of interleukin-mediated cell activation.

    Summary:

    • This review synthesizes current knowledge on lymphokines and monokines, highlighting their functions in specific immune responses.
    • It examines the role of interleukins in the generation of cytolytic T-lymphocytes, illustrating antigen-interleukin interactions.

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  • The review discusses signal transduction pathways and secondary messengers involved in interleukin activity, despite incomplete elucidation.

    • Impact:

    • Provides a comprehensive overview of cytokine roles in immunity.
    • Suggests a framework for defining interleukins based on functional and structural characteristics.
    • Highlights the need for further research into interleukin-mediated cell activation pathways.