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Integrated Photoacoustic Ophthalmoscopy and Spectral-domain Optical Coherence Tomography
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Internal-illumination photoacoustic computed tomography.

Mucong Li1, Bangxin Lan1, Wei Liu1

  • 1Duke University, Department of Biomedical Engineering, Durham, North Carolina, United States.

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|March 25, 2018
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Summary

This study introduces an improved photoacoustic computed tomography (PACT) system with internal fiber optic illumination. This novel approach significantly enhances imaging depth for deep tissue visualization in preclinical and clinical settings.

Keywords:
deep imagingfiber diffuserinternal illuminationphotoacoustic computed tomographyphotoacoustic imaging

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Area of Science:

  • Biomedical Optics
  • Medical Imaging
  • Photoacoustics

Background:

  • Traditional photoacoustic computed tomography (PACT) is limited by shallow imaging depths due to optical scattering and attenuation.
  • External light sources struggle to penetrate deep tissues effectively, hindering visualization of deeper organs.

Purpose of the Study:

  • To develop and evaluate a novel PACT system utilizing internal fiber optic illumination for enhanced deep-tissue imaging.
  • To overcome the penetration depth limitations of conventional external illumination PACT.

Main Methods:

  • A customized optical fiber with a cylindrical diffuser was employed for homogeneous internal light delivery.
  • The system integrated internal illumination with external ultrasound detection.
  • Performance was characterized using tissue phantoms and in vivo animal models.

Main Results:

  • The internal illumination PACT system demonstrated superior imaging depth compared to external illumination.
  • A 7.5-cm-deep leaf target in scattering medium and a mouse heart through 3.7 cm of chicken tissue were successfully imaged.
  • Homogeneous illumination and an enlarged field of view were achieved with the conoid needle diffuser.

Conclusions:

  • Internal light illumination combined with external ultrasound detection is a promising strategy for deep-penetration PACT.
  • This approach holds potential for imaging deep organs in large animals and humans.
  • The developed PACT system offers a significant advancement in deep-tissue optical imaging.