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Rotavirus surveillance in Pakistan during 2015-2016 reveals high prevalence of G12P[6]

Massab Umair1,2, Muhammad Salman1, Muhammad Masroor Alam1

  • 1Department of Virology, National Institute of Health, Chak Shahzad, Islamabad, Pakistan.

Journal of Medical Virology
|March 25, 2018
PubMed

Insights

The G12 rotavirus genotype, a rare cause of gastroenteritis globally, was found to be a significant contributor to childhood rotavirus gastroenteritis in Pakistan between 2015-2016. This finding highlights the importance of ongoing surveillance for rotavirus strains in the country.

Area of Science:

  • Virology
  • Epidemiology
  • Public Health

Background:

  • The G12 rotavirus genotype has emerged globally since 1987.
  • G12 remains a rare cause of gastroenteritis in Pakistan.

Purpose of the Study:

  • To determine the prevalence and genetic characteristics of rotavirus genotypes, including G12, in Pakistani children hospitalized with gastroenteritis.

Main Methods:

  • Rotavirus surveillance in hospitalized children (<5 years) from 2015-2016.
  • ELISA for rotavirus detection and genotyping of positive samples.
  • Phylogenetic analysis of G12 strains.

Main Results:

  • 802 out of 3446 children (23.2%) tested positive for rotavirus.
  • G12P[6] was the third most common G/P combination (11.28%), following G3P[8] and G1P[8].
  • Pakistani G12 strains showed high genetic similarity to international strains and local lineage III strains.

Conclusions:

  • G12P[6] significantly contributed to rotavirus gastroenteritis in Pakistani children.
  • Continued surveillance is crucial to monitor the evolution of G12 and other rotavirus genotypes, especially post-vaccine introduction.

Keywords:
G12Pakistanepidemiologyrotavirus

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