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Electroencephalographic correlates of low-frequency vagus nerve stimulation therapy for Crohn's disease
Astrid Kibleur1, Sonia Pellissier2, Valérie Sinniger3
1Univ. Grenoble Alpes, F-38000 Grenoble, France; Inserm, U1216, Grenoble Institut des Neurosciences, F-38000 Grenoble, France.
Objectives:
In the context of the first clinical trial of vagus nerve stimulation (VNS) in Crohn's disease (CD), our main objective was to quantify the acute and chronic effects of VNS on brain activity in CD patients.
Methods:
We measured the electroencephalogram (EEG) in 9CD patients under VNS at 10 Hz just before VNS initiation, after 6 weeks and after 12 months of chronic VNS.
Results:
Acute VNS induced increased spectral power in delta and theta bands on frontal, temporal and occipital electrodes. The main significant modulation was the 12 months' chronic effect of VNS which consisted mainly in a decreased power in the alpha frequency band which was correlated with the normalization of bowel mucosal inflammation, anxiety state and vagal tone.
Conclusions:
In addition to the activation of vagal efferent fibers that regulate the autonomic nervous system, our data suggest that chronic VNS has a regulatory action via afferent vagal fibers on anxio-depressive symptomatology associated to CD, which could be directly highlighted by the modulation of EEG alpha power known to be associated to depressed states.
Significance:
This is the first report of the central effects of VNS in CD patients.