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A-L Rémond1, E Barreau2, P Le Hoang1

  • 1Hôpital Pitié-Salpêtrière, 47-83, boulevard de l'Hôpital, 75013 Paris, France.

Journal Francais D'Ophtalmologie
|March 26, 2018
PubMed
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New immunotherapies like nivolumab can cause rare but serious eye inflammation (immune-related ocular toxicities). Careful diagnosis and management are key for patients receiving these cancer treatments.

Area of Science:

  • Oncology
  • Immunology
  • Ophthalmology

Background:

  • Immune pathway inhibitors are novel anticancer therapies.
  • Immune-related adverse events (IRAE) can occur with these treatments.
  • Immune-related ocular toxicities are rare but serious complications.

Observation:

  • This article details a case of ocular inflammatory involvement.
  • The inflammation was potentially linked to nivolumab, an immunologic agent for solid tumors.
  • Other potential causes of ocular inflammation were ruled out.

Findings:

  • Nivolumab therapy may be associated with ocular inflammation.
  • Continuation of nivolumab may be considered based on individual patient risk/benefit.
  • Ophthalmologists and oncologists must collaborate for diagnosis and management.
Keywords:
Anti-PD1Check point inhibitorsChemotherapyDrug induced uveitisNivolumabPosterior uveitisUveitis

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Implications:

  • Early recognition and management of ocular IRAE are crucial.
  • Multidisciplinary collaboration improves patient outcomes for cancer immunotherapy.
  • Risk-benefit assessment is vital for continuing nivolumab in cases of ocular toxicity.