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[Ocular surface aging: Pathophysiology and consequences for management].

T Audelan1, M Legrand1, M M'Garrech1

  • 1Service d'ophtalmologie, hôpital de Bicêtre, Assistance publique-Hôpitaux de Paris, DHU vision et handicap, université Paris-Sud, Le Kremlin-Bicêtre, 78, rue du Général-Leclerc, 94275 Le Kremlin-Bicêtre cedex, France.

Journal Francais D'Ophtalmologie
|March 26, 2018
PubMed
Summary
This summary is machine-generated.

Aging significantly impacts the ocular surface and lacrimal system, leading to various age-related eye conditions. Understanding these changes is crucial for effectively managing ocular surface diseases in older adults.

Keywords:
AgingDry eyeEyelid ptosisOcular surfacePtose palpébraleSurface oculaireSécheresse oculaireVieillissement

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Area of Science:

  • Ophthalmology
  • Gerontology
  • Ocular Surface Disease

Background:

  • Aging affects all ocular surface and lacrimal system components.
  • Age-related changes include lacrimal gland fibrosis, Meibomian gland dysfunction, and reduced corneal sensitivity.
  • Ocular surface homeostasis is further disrupted by systemic comorbidities and medical interventions.

Purpose of the Study:

  • To review the multifaceted effects of aging on the ocular surface.
  • To highlight aging as the primary risk factor for dry eye disease.
  • To discuss how understanding aging pathophysiology can improve ocular surface disease management in the elderly.

Main Methods:

  • Literature review of age-related changes in the ocular system.
  • Analysis of the impact of aging on ocular surface structures and functions.
  • Synthesis of current knowledge on the pathophysiology of ocular aging.

Main Results:

  • Aging causes significant structural and functional decline in the ocular surface and lacrimal system.
  • Key age-induced changes include inflammation, immune impairment, and reduced cell density.
  • Aging is identified as the predominant risk factor for dry eye disease.

Conclusions:

  • Aging profoundly alters the ocular surface, increasing susceptibility to disease.
  • Improved understanding of ocular aging mechanisms facilitates better clinical management strategies.
  • Targeting age-related pathways offers potential for novel therapeutic approaches in elderly patients.