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Updated: Feb 12, 2026
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The WATCHMAN Left Atrial Appendage Closure Device for Atrial Fibrillation
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Left-Sided Atrial Septal Pouch is a Risk Factor for Cryptogenic Stroke
Mateusz K Hołda1, Agata Krawczyk-Ożóg2, Mateusz Koziej1
1Heart Embryology and Anatomy Research Team, Department of Anatomy, Jagiellonian University Medical College, Cracow, Poland.
Summary
The presence of a left-sided septal pouch (LSSP) is linked to a higher risk of cryptogenic stroke. Further clinical evaluation of LSSPs is recommended for stroke risk assessment.
Area of Science:
- Cardiology
- Neurology
- Medical Imaging
Background:
- The left-sided septal pouch (LSSP) is an anatomical variation of the interatrial septum.
- Its morphology may promote blood stasis, increasing the risk of thromboembolic events.
Purpose of the Study:
- To investigate the association between the presence of LSSP and cryptogenic stroke.
- To determine if LSSP is an independent risk factor for cryptogenic stroke.
Main Methods:
- Retrospective analysis of 126 cryptogenic stroke patients and 137 age-matched controls.
- Transesophageal echocardiography was used to assess LSSP presence and dimensions.
Main Results:
- LSSP was found in 55.6% of cryptogenic stroke patients versus 40.9% of controls (P=.02).
- Univariate analysis showed LSSP was associated with increased cryptogenic stroke risk (OR, 1.81).
- Multivariable analysis confirmed LSSP as an independent risk factor (OR, 2.02; P=.01).
Conclusions:
- An association exists between LSSP presence and an elevated risk of cryptogenic stroke.
- Clinical evaluation of LSSPs warrants increased attention for stroke risk stratification.
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