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Updated: Feb 12, 2026

Bioorthogonal Chemical Imaging of Cell Metabolism Regulated by Aromatic Amino Acids
Published on: May 12, 2023
Inositol to aromatics -benzene free synthesis of poly oxygenated aromatics
Bharat P Gurale1, Mysore S Shashidhar1, Richa S Sardessai1
1The Division of Organic Chemistry, CSIR-National Chemical Laboratory, Pashan Road, Pune, 411 008, India.
Abstract:
A method for the preparation of benzene derivatives from myo-inositol, an abundantly available phyto chemical is described. 1,3-Bridged acetals of inososes undergo step-wise elimination leading to the formation of polyoxygenated benzene derivatives. This aromatization reaction proceeds through the intermediacy of a β-alkoxyenone, which could be isolated. This sequence of reactions starting from myo-inositol, provides a novel route for the preparation of polyoxygenated benzene derivatives including polyoxygenated biphenyl. This scheme of synthesis demonstrates the potential of myo-inositol as a sustainable non-petrochemical resource for aromatic compounds.
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