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Updated: Feb 12, 2026

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A non-canonical tumor suppressive role for the long non-coding RNA MALAT1 in colon and breast cancers

Zhi Hao Kwok1, Veronique Roche1, Xiao Hong Chew1

  • 1Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore.

International Journal of Cancer
|March 26, 2018
PubMed

Insights

The tumor suppressor PTEN regulates the long noncoding RNA MALAT1 via microRNAs. This newly identified axis reveals MALAT1

Area of Science:

  • Molecular Biology
  • Genetics
  • Oncology

Background:

  • Long noncoding RNAs (lncRNAs) are implicated in various diseases, particularly cancer.
  • Dysregulation of lncRNAs, including metastasis associated lung adenocarcinoma transcript 1 (MALAT1), plays critical roles in tumorigenesis.
  • The interplay between protein-coding genes and the noncoding transcriptome is complex, involving oncogenes and tumor suppressors.

Purpose of the Study:

  • To investigate the impact of PTEN tumor suppressor dysregulation on the noncoding transcriptome.
  • To identify and characterize the regulatory axis involving PTEN, microRNAs, and MALAT1 in tumorigenesis.

Main Methods:

  • Investigated PTEN's effect on the noncoding transcriptome.
  • Identified MALAT1 as a target of PTEN regulation.
  • Characterized the microRNA-dependent mechanisms mediating PTEN-MALAT1 crosstalk.

Main Results:

  • PTEN dysregulation affects the lncRNA MALAT1.
  • This PTEN-MALAT1 regulation is conserved across species and PTEN dysregulation types.
  • A non-canonical PTEN-microRNA-MALAT1 axis regulating tumorigenesis was established and characterized.
  • MALAT1 exhibits novel tumor-suppressive properties in colon and breast cancers.

Conclusions:

  • Established a novel PTEN-microRNA-MALAT1 regulatory axis.
  • Demonstrated MALAT1's tumor-suppressive role in colon and breast cancers.
  • Highlighted the significance of noncoding RNA regulation in cancer development.
Keywords:
PTENcancerinvasionlong non-coding RNAmicroRNAmigration

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