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Updated: Feb 12, 2026

In Silico Clinical Trials for Cardiovascular Disease
Published on: May 27, 2022
Design and Endpoints for Clinical Trials in Primary Sclerosing Cholangitis
Cyriel Y Ponsioen1, Keith D Lindor2, Ruby Mehta3
1Department of Gastroenterology & Hepatology, Academic Medical Center, Amsterdam, The Netherlands.
Abstract:
Primary sclerosing cholangitis (PSC) is a rare and chronic liver disease for which there is no effective therapy. Interest has grown in developing treatments for this condition, with several agents proposed as potential therapies. However, there is a lack of clarity about how to measure clinical benefit in trials involving patients with this complex and rare disease. This article reviews regulatory information, the available literature on natural history, as well as potential candidate clinical and surrogate endpoints for PSC. (Hepatology 2018; 00:000-000).
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