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Mechanical bacterial lysate administration prevents exacerbation in allergic asthmatic children-The EOLIA study

Andrzej Emeryk1, Malgorzata Bartkowiak-Emeryk2, Zbigniew Raus3

  • 1Department of Paediatric Pulmonology and Rheumatology, University Children Hospital of Lublin, Lublin, Poland.

Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology
|March 26, 2018
PubMed

Insights

Polyvalent Mechanical Bacterial Lysate (PMBL) tablets significantly reduced asthma exacerbations in allergic children. This safe treatment offers a new approach for managing asthma in school-aged children.

Area of Science:

  • Pediatric Allergy and Immunology
  • Respiratory Medicine
  • Pharmacology

Background:

  • Asthma exacerbations remain a challenge in school-aged children with allergic asthma.
  • New therapeutic strategies are needed for effective asthma management.
  • Previous studies indicated bacterial lysates can reduce wheezing in younger children.

Purpose of the Study:

  • To evaluate the efficacy of Polyvalent Mechanical Bacterial Lysate (PMBL) tablets in managing allergic asthma in children aged 6-16.
  • To assess the impact of PMBL on asthma control and exacerbation rates.

Main Methods:

  • A randomized, double-blind, placebo-controlled study involving 152 children with allergic asthma.
  • Participants received either PMBL tablets or a placebo over a 9-month period.
  • Asthma control was assessed using the Asthma Control Test (ACT/C-ACT) score.

Main Results:

  • While the primary endpoint (ACT/C-ACT changes) was not met, PMBL significantly reduced the number of asthma exacerbations at 12 weeks and throughout the study.
  • Patients on PMBL experienced fewer exacerbation days and a prolonged time to subsequent exacerbations.
  • No serious adverse events were associated with PMBL administration.

Conclusions:

  • PMBL tablets are a safe and effective option for reducing asthma exacerbations in school-aged children with allergic asthma.
  • This treatment shows promise in improving the clinical course of allergic asthma in pediatric populations.
  • Further research may explore long-term effects and broader applications of PMBL.
Abstract

Keywords:
PMBL® Tabletallergic asthmachildrenexacerbation

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