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Lack of association between SLCO1B1 polymorphisms and lipid-lowering response to simvastatin therapy in Thai

N Kaewboonlert1, W Thitisopee2, W Sirintronsopon3

  • 1School of Allied Health Sciences, Walailak University, Nakhon Si Thammarat, Thailand.

Journal of Clinical Pharmacy and Therapeutics
|March 26, 2018
PubMed

Insights

Genetic variations in SLCO1B1 (solute carrier organic anion transporter family member 1B1) did not predict simvastatin

Area of Science:

  • Pharmacogenomics
  • Cardiovascular Medicine
  • Molecular Biology

Background:

  • SLCO1B1 gene polymorphisms are known to influence statin therapy response.
  • Previous studies show inconsistent associations between SLCO1B1 variants and lipid-lowering effects.

Purpose of the Study:

  • To examine the impact of SLCO1B1 c.388A>G, c.521T>C, and g.89595T>C polymorphisms on simvastatin's lipid-lowering efficacy.
  • The study focused on Thai patients with hypercholesterolemia.

Main Methods:

  • Genotyping of SLCO1B1 polymorphisms (c.388A>G, c.521T>C, g.89595T>C) using PCR-HRM.
  • Analysis of serum lipid profiles (TC, TG, LDL-C, HDL-C) in 391 hypercholesterolemic patients before and after 3 or 12 months of simvastatin treatment (20-40 mg/day).

Main Results:

  • Simvastatin significantly reduced TC, TG, and LDL-C levels after 3 and 12 months (P < .05).
  • No significant changes in HDL-C levels were observed.
  • No association was found between the studied SLCO1B1 polymorphisms and the lipid-lowering response to simvastatin.

Conclusions:

  • The investigated SLCO1B1 polymorphisms (c.388A>G, c.521T>C, g.89595T>C) are unlikely to serve as reliable genetic markers for predicting simvastatin response in Thai hypercholesterolemic patients.
Abstract

Keywords:
SLCO1B1hypercholesterolaemiapolymorphismsresponsesimvastatin

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