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Primary graft infections.

W H Edwards, R S Martin, J M Jenkins

    Journal of Vascular Surgery
    |September 1, 1987
    PubMed
    Summary
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    Vascular prosthetic graft infections are severe complications. This study found an infection rate of 0.92% in 2614 grafts, with Staphylococcus aureus being common and leading to high amputation and mortality rates.

    Area of Science:

    • Vascular Surgery
    • Infectious Diseases
    • Biomaterials

    Background:

    • Vascular prosthetic graft infections are a serious complication with high amputation and mortality rates.
    • Previous studies suggested prophylactic antibiotics may reduce infection rates, but evidence was limited.

    Purpose of the Study:

    • To determine the incidence and characteristics of vascular prosthetic graft infections.
    • To analyze outcomes in patients with infected grafts.

    Main Methods:

    • Retrospective review of 2614 arterial prosthetic grafts implanted between January 1975 and June 1986.
    • Identification and analysis of 24 cases of prosthetic graft infection.

    Main Results:

    • Overall infection rate was 0.92%. Staphylococcus aureus was the most common pathogen.

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  • Polytetrafluoroethylene (PTFE) and Dacron were the most frequent graft materials. Diabetes was a common comorbidity.
  • Infected grafts required prosthesis removal, resulting in 17% limb loss and 17% mortality. Many infections presented within 3 months of surgery.

    • Conclusions:

    • Vascular prosthetic graft infections remain a significant challenge with severe consequences.
    • While prophylactic antibiotics were often used, their administration varied, potentially impacting efficacy.
    • Infection necessitates graft removal, leading to high rates of limb loss and mortality.