Familial papular epidermal nevus with "skyline" basal cell layer

Area of Science:

• Dermatology
• Genetics

Background:

• Papular epidermal nevus with "skyline" basal cell layer is a rare keratinocytic nevus variant.
• Typically, this condition occurs sporadically, but familial occurrences have been documented.

Observation:

• This report describes the fourth documented family with this condition.
• The affected individuals are a 3-month-old girl and her father.

Findings:

• The study highlights a familial transmission pattern of papular epidermal nevus with "skyline" basal cell layer.
• This case adds to the limited understanding of the genetic basis of this rare nevus variant.

Implications:

• Further research into the genetic factors underlying familial papular epidermal nevus with "skyline" basal cell layer is warranted.
• Understanding familial patterns can aid in genetic counseling and early diagnosis.