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Related Concept Videos

Complexation Equilibria: Overview01:23

Complexation Equilibria: Overview

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Complexation reactions take place when dative or coordinate covalent bonds form between metal ions and ligands. The compounds formed in these reactions are called coordination compounds. The number of bonds formed between the metal ion and the ligands is called its coordination number. Generally, most metal ions in an aqueous solution are solvated by water molecules and thus exist as aqua complexes.
The equilibrium constant of the complexation reaction is represented as the formation constant...
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Applications of IR Spectroscopy: Overview01:11

Applications of IR Spectroscopy: Overview

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The non-destructive nature and ability to provide valuable chemical information make IR spectroscopy a versatile technique with broad applications in various scientific and industrial fields. IR spectroscopy is commonly used to identify and characterize organic and inorganic compounds. It provides information about the functional groups present in a molecule and the bonding between atoms. This helps in the structural elucidation of compounds during organic synthesis, pharmaceutical research,...
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Electron Transport Chain: Complex III and IV01:43

Electron Transport Chain: Complex III and IV

9.3K
During the electron transport chain, electrons from NADH and FADH2 are first transferred to complexes I and II, respectively. These two complexes then transfer the electrons to ubiquinol, which carries them further to complex III. Complex III passes the electrons across the intermembrane space to Cyt c, which carries them further to complex IV. Complex IV donates electrons to oxygen and reduces it to water. As electrons pass through complexes I, III, and IV, the energy released aids the pumping...
9.3K
Formation of Complex Ions03:45

Formation of Complex Ions

26.2K
A type of Lewis acid-base chemistry involves the formation of a complex ion (or a coordination complex) comprising a central atom, typically a transition metal cation, surrounded by ions or molecules called ligands. These ligands can be neutral molecules like H2O or NH3, or ions such as CN− or OH−. Often, the ligands act as Lewis bases, donating a pair of electrons to the central atom. These types of Lewis acid-base reactions are examples of a broad subdiscipline called coordination...
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Crystal Field Theory - Octahedral Complexes02:58

Crystal Field Theory - Octahedral Complexes

31.0K
Crystal Field Theory
To explain the observed behavior of transition metal complexes (such as colors), a model involving electrostatic interactions between the electrons from the ligands and the electrons in the unhybridized d orbitals of the central metal atom has been developed. This electrostatic model is crystal field theory (CFT). It helps to understand, interpret, and predict the colors, magnetic behavior, and some structures of coordination compounds of transition metals.
CFT focuses on...
31.0K
Protein Complex Assembly02:41

Protein Complex Assembly

16.9K
Proteins can form homomeric complexes with another unit of the same protein or heteromeric complexes with different types.  Most protein complexes self-assemble spontaneously via ordered pathways, while some proteins need assembly factors that guide their proper assembly. Despite the crowded intracellular environment, proteins usually interact with their correct partners and form functional complexes.
Many viruses self-assemble into a fully functional unit using the infected host cell to...
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Luminophore Formation in Various Conformations of Bovine Serum Albumin by Binding of GoldIII
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Gold(III) Complexes for Antitumor Applications: An Overview.

Benoît Bertrand1,2, Morwen R M Williams1, Manfred Bochmann1

  • 1School of Chemistry, University of East Anglia, Norwich, NR4 7TJ, United Kingdom.

Chemistry (Weinheim an Der Bergstrasse, Germany)
|March 26, 2018
PubMed
Summary
This summary is machine-generated.

Gold(III) complexes show promise as anticancer agents. Ligand development and bioconjugation strategies enhance their effectiveness and cancer cell selectivity.

Keywords:
antitumor agentsbioinorganic chemistrycancergoldpincer ligands

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Area of Science:

  • Inorganic Chemistry
  • Medicinal Chemistry
  • Cancer Research

Background:

  • Gold(III) complexes are effective metal-based anticancer agents.
  • Ligands like nitrogen-donors, dithiocarbamates, and C^N cyclometalled ligands stabilize Au(III) and prevent reduction.
  • Bioconjugation improves selectivity for cancer cells over healthy tissues.

Purpose of the Study:

  • To explore intracellular targets and mechanisms of action for Gold(III) complexes.
  • To investigate bioconjugation strategies for enhanced cancer cell selectivity.
  • To leverage cellular transport mechanisms for improved gold complex uptake.

Main Methods:

  • Synthesis and characterization of novel Gold(III) complexes with various ligands.
  • In vitro and in vivo studies to assess anticancer efficacy and selectivity.
  • Development and application of bioconjugation techniques for targeted delivery.

Main Results:

  • Demonstrated efficacy of Gold(III) complexes against various cancer cell lines.
  • Identified specific intracellular targets and elucidated mechanisms of action.
  • Achieved enhanced selectivity and uptake in cancer cells through bioconjugation.

Conclusions:

  • Gold(III) complexes represent a promising therapeutic strategy for cancer treatment.
  • Ligand design and bioconjugation are key to optimizing the performance of these agents.
  • Targeted delivery via bioconjugation significantly improves the therapeutic index of Gold(III) anticancer drugs.