Related Experiment Video
Updated: Feb 12, 2026

Author Spotlight: Investigating Immune Cell Dynamics in the Tumor Microenvironment — Challenges and Innovations in Cancer Prognosis
Published on: April 12, 2024
C-reactive protein is an independent prognostic marker in patients with tongue carcinoma - A retrospective study
M Graupp1, K Schaffer1, A Wolf1
1Department of Otorhinolaryngology, Head and Neck surgery, Medical University of Graz, Graz, Austria.
Objectives:
Reliable prognostic markers are lacking for tongue carcinoma. C-reactive protein (CRP) and a ratio from neutrophils/lymphocytes (NLR) are biomarkers, associated with prognosis in solid cancers. Aim of this work was to investigate the role of CRP and NLR in prognosis of patients with tongue carcinoma.
Design:
Retrospective cohort study.
Setting:
We retrospectively analysed data of patients treated for tongue carcinoma at our institution. Levels of CRP, Neutrophils and Lymphocytes were measured pretherapeutic.
Participants:
197 patients treated for squamous cell carcinoma of the tongue between 2002 and 2015.
Main Outcome Measures:
Overall survival, disease-free survival.
Results:
Elevated CRP was significantly associated with shorter overall survival in our cohort in uni- and multivariate analysis. NLR was not associated with prognosis.
Conclusion:
In the present study we could confirm the role of CRP as an independent prognostic marker in patients with tongue carcinoma. Incorporating this marker in prognostication could represent a valuable and moreover inexpensive tool for improved decisions making concerning therapy in the future.
More Related Videos
Related Concept Videos
Tongue
Anatomical Position in the Oral Cavity
The tongue is located within the oral cavity, also known as the mouth. It is attached to the floor of the mouth by a fold of mucous membrane called the...
Tip-of-the-Tongue Phenomenon
Introduction to Test of Independence
The test statistic for a test of independence is similar to that of a goodness-of-fit test:
Hypothesis Test for Test of Independence
H0: The two variables (factors)...
The Tongue and Taste Buds
Law of Independent Assortment

