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Quantification of three DNA Lesions by Mass Spectrometry and Assessment of Their Levels in Tissues of Mice Exposed to Ambient Fine Particulate Matter
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Postfolate spina bifida lesion level change.

Carin Eldridge1, Sruti Bandlamuri2, Jennifer G Andrews2

  • 1School of Medicine, University of Arizona, Tucson, Arizona.

Birth Defects Research
|March 26, 2018
PubMed
Summary
This summary is machine-generated.

Folate fortification significantly reduced severe spina bifida (SB) lesions, particularly at the thoracic level. This highlights fortification

Keywords:
folic acidfortificationlesion levelmyelomeningocelespina bifida

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Area of Science:

  • Neurology
  • Public Health
  • Pediatrics

Background:

  • Spina bifida (SB) is a major birth defect in the U.S.
  • Folate fortification's impact on SB prevalence is known, but its effect on neurologic function is less understood.
  • This study investigates changes in SB lesion levels before and after food fortification.

Purpose of the Study:

  • To assess the functional neurologic level of spina bifida lesions in the pre- and post-folate fortification eras.
  • To determine if folate fortification has altered the distribution of SB lesion severity.

Main Methods:

  • Retrospective review of medical records from a regional clinic in Arizona.
  • Inclusion criteria: Spina bifida diagnosis (with or without hydrocephalus), born between 1981-1995 (prefortification) and 1999-2013 (postfortification).
  • Comparison of lesion levels between the two eras.

Main Results:

  • Significant difference in functional lesion levels observed post-fortification.
  • An 85% reduction in thoracic level lesions was noted in the postfortification era (p < .005).
  • Mid-lumbar lesions remained the most common type in both eras.

Conclusions:

  • Folate fortification is associated with a significant shift in the distribution of spina bifida lesion levels.
  • The findings suggest a potential improvement in neurologic function related to SB in the post-fortification era.
  • Further national studies with larger sample sizes are recommended to validate these observations.