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Relation of locus 1p13 rs646776 polymorphism with the risk of preeclampsia
Rana H Emam1, Maivel H Ghattas2, Noha M Mesbah1
1a Faculty of Pharmacy, Department of Biochmistry , Suez Canal University , Ismailia , Egypt.
Insights
The rare C allele of the rs646776 polymorphism is linked to a reduced risk of preeclampsia. This genetic factor may influence endothelin-1 levels and blood pressure in pregnant Egyptian women.
Area of Science:
- Genetics
- Obstetrics
- Cardiovascular Medicine
Background:
- Preeclampsia is a serious pregnancy complication.
- Genetic factors influence preeclampsia susceptibility.
- The 1p13.3 locus rs646776 polymorphism is a potential candidate gene.
Purpose of the Study:
- To investigate the association between the 1p13.3 rs646776 (T/C) polymorphism and preeclampsia in Egyptian women.
- To evaluate the relationship between genotypes and clinical parameters.
Main Methods:
- Case-control study involving 100 preeclampsia patients and 100 healthy pregnant women.
- Genotyping of the rs646776 polymorphism.
- Measurement of plasma endothelin-1 levels.
Main Results:
- The T allele of rs646776 was more frequent in preeclampsia patients.
- Carriers of the C allele exhibited lower endothelin-1 levels.
- C allele carriers showed reduced blood pressure, less proteinuria, and higher HDL-C.
Conclusions:
- The rare C allele of the rs646776 polymorphism at chromosomal locus 1p13.3 is associated with a decreased risk of preeclampsia.
- This finding suggests a protective role for the C allele.
- The polymorphism may influence preeclampsia pathogenesis through endothelin-1 pathways.
Objective:
This study aimed to assess the relation of locus 1p13 rs646776 (T/C) polymorphism with preeclampsia in Egyptian women.
Methods:
The study included 100 healthy pregnant female subjects and 100 preeclampsia patients. The genotypes of the polymorphisms were assessed. Endothelin-1 level was determined in plasma.
Results:
The major T allele of the 1p13.3 genomic region rs646776 polymorphism had a higher frequency in preeclampsia patients. Carriers of C allele had significantly lower endothelin-1 levels, lower systolic and diastolic blood pressure, decreased proteinuria, and increased HDL-C in the patients.
Conclusion:
The rare C allele of rs646776 polymorphism in chromosomal locus 1p13.3 is associated with decreased risk of preeclampsia.
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