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Published on: April 1, 2019
CD36 gene polymorphism and plasma sCD36 as the risk factor in higher cholesterolemia
M E Rać1, K Safranow1, B Garanty-Bogacka2
1Department of Biochemistry and Medical Chemistry, Pomeranian Medical University, Powstańców Wielkopolskich 72, 70-111 Szczecin, Poland.
Insights
Higher soluble CD36 (sCD36) levels in children may protect against metabolic syndrome. The CD36 gene IVS4-10A allele is linked to lower hypercholesterolemia risk.
Area of Science:
- Genetics
- Biochemistry
- Pediatrics
Background:
- The CD36 receptor is implicated in atherogenicity.
- Understanding CD36's role in pediatric metabolic health is crucial.
Purpose of the Study:
- To investigate the association between CD36 gene polymorphisms and soluble CD36 (sCD36) plasma levels with clinical and biochemical parameters in children.
- To explore the relationship between CD36 and hypercholesterolemia in pediatric populations.
Main Methods:
- Study included Caucasian children with and without hypercholesterolemia.
- CD36 gene alterations were identified using DHPLC.
- Plasma sCD36 concentrations were quantified via ELISA.
Main Results:
- The CD36 IVS4-10A allele (rs3211892) showed an association with reduced hypercholesterolemia risk.
- sCD36 concentration negatively correlated with uric acid, insulin, HOMA-IR, weight, waist/hip circumference, systolic blood pressure, BMI, waist-hip ratio, and mean arterial pressure.
- sCD36 concentration positively correlated with HDL cholesterol and ApoA1.
- Female gender was an independent predictor of higher sCD36 levels.
Conclusions:
- Elevated sCD36 concentrations may offer a protective effect against components of the metabolic syndrome in children.
- Findings suggest a potential role for CD36 in pediatric metabolic health and cardiovascular risk.
Introduction:
The receptor CD36 has been reported to play an important role in atherogenicity. The aim of this study was to gain insight into the relationship between CD36 gene polymorphisms or the plasma concentration of sCD36 and clinical or biochemical parameters in children.
Patients And Methods:
The study groups comprised Caucasian children with and without hypercholesterolemia. The alterations in the CD36 gene were detected by DHPLC and the plasma concentrations of sCD36 were measured by ELISA.
Results:
The data presented suggest that the IVS4-10A allele of CD36 (rs3211892) is associated with a lower risk of hypercholesterolemia. We observed a negative correlation of the sCD36 concentration with uric acid and insulin concentrations, the HOMA-IR ratio, weight, waist and hip circumference, systolic blood pressure, body mass index, waist-hip ratio and mean arterial pressure ratio, but a positive correlation with HDL cholesterol and ApoA1 concentrations. Female gender was a significant independent predictor of a higher plasma sCD36 concentration.
Conclusions:
The data presented suggest a possible protective effect of a higher sCD36 concentration in relation to metabolic syndrome components.
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