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Normalization and the Cholinergic Microcircuit: A Unified Basis for Attention
Taylor W Schmitz1, John Duncan2
1Montreal Neurological Institute, Department of Neurology and Neurosurgery, McGill University, 3801 rue University, Montreal, QC, H3A 2B4, Canada.
Abstract:
Attention alters three key properties of population neural activity - firing rate, rate variability, and shared variability between neurons. All three properties are well explained by a single canonical computation - normalization - that acts across hierarchically integrated brain systems. Combining data from rodents and nonhuman primates, we argue that cortical cholinergic modulation originating from the basal forebrain closely mimics the effects of directed attention on these three properties of population neural activity. Cholinergic modulation of the cortical microcircuit underlying normalization may represent a key biological basis for the rapid and flexible changes in population neuronal coding that are required by directed attention.
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