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A Syngeneic Murine Model of Endometriosis using Naturally Cycling Mice
Published on: November 24, 2020
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Pathogenesis of endometriosis: Interaction between Endocrine and inflammatory pathways
Bansari G Patel1, Emily E Lenk1, Dan I Lebovic2
1Department of Obstetrics and Gynecology, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA.
Best Practice & Research. Clinical Obstetrics & Gynaecology
|March 27, 2018
Summary
Endometriosis, affecting 11% of women, involves complex hormonal and immune factors creating inflammation. Novel therapeutics targeting both systems offer new treatment options for this gynecologic syndrome.
Area of Science:
- Gynecology
- Immunology
- Endocrinology
Background:
- Endometriosis affects 11% of women, with poorly understood etiology despite historical recognition.
- Clinical presentation is variable, with no clear correlation between symptoms and disease extent.
Purpose of the Study:
- To review classical theories on endometriosis origins.
- To synthesize evidence on hormonal and immune factors in endometriosis pathogenesis.
- To explore novel therapeutics targeting dual endocrine and immune pathways.
Main Methods:
- Review of classical theories of endometriosis histological origins.
- Synthesis of current evidence on hormonal and immune factor involvement.
- Analysis of emerging therapeutic compounds with dual pharmacological actions.
Main Results:
- Hormonal and immune factors interact to create an inflammatory microenvironment promoting endometriosis.
- This inflammatory environment mediates pain and infertility, the cardinal symptoms.
- Some novel compounds exhibit dual activity on both endocrine and immune systems.
Conclusions:
- Endometriosis pathogenesis involves a complex interplay of endocrine and immune dysregulation.
- Targeting both facets simultaneously may offer more effective therapeutic strategies.
- Future drug development holds promise for improved patient treatment choices.
Keywords:
EndometriosisEstrogenGnRH (gonadotropin-releasing hormone)ProgesteroneSERM (selective estrogen receptor modulator)More Related Videos
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