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A low cost, membranes based serum separator modular.

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    This study introduces a low-cost, membrane-based serum separator for microfluidic devices, enabling rapid sample preparation in resource-limited settings. The innovative design achieves efficient serum separation without centrifugation, crucial for sensitive diagnostic assays.

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    Area of Science:

    • Biomedical Engineering
    • Clinical Diagnostics
    • Materials Science

    Background:

    • Microfluidic systems require efficient sample preparation for "sample in, answer out" testing.
    • Resource-limited clinical facilities urgently need low-cost, user-friendly diagnostic tools.

    Purpose of the Study:

    • To develop a cost-effective, membrane-based serum separator for microfluidic analysis.
    • To enable rapid and reliable serum separation from whole blood samples.

    Main Methods:

    • Design and fabrication of a specialized microchip with a membrane-based serum separator.
    • Evaluation of serum and protein recovery rates compared to traditional centrifugation methods.
    • Assessment of the device's suitability for various diagnostic assays.

    Main Results:

    • The device separates serum from whole blood in 5 minutes.
    • Achieved a serum volume recovery rate of approximately 73% and a protein recovery rate of 70-95%.
    • Yielded 50-70 μl of serum from a 300 μl whole blood sample.

    Conclusions:

    • The proposed membrane-based serum separator is a viable, low-cost solution for microfluidic sample preparation.
    • The device provides sufficient purified serum for diagnostic assays like immunoassays and nucleic acid tests.
    • This technology addresses the need for accessible diagnostics in resource-limited clinical settings.