Malignant Peritoneal Mesothelioma Presenting as Mucinous Ascites

Area of Science:

• Gastroenterology
• Oncology
• Pathology

Background:

• Malignant peritoneal mesothelioma (MPM) is a rare cancer, distinct from the more common pleural mesothelioma.
• While asbestos exposure is a known risk factor for pleural mesothelioma, peritoneal mesothelioma has varied etiologies.
• Peritoneal mesothelioma accounts for 6-10% of all mesothelioma cases.

Observation:

• A 46-year-old male presented with mucinous ascites, an unusual clinical manifestation.
• Diagnostic colonoscopy with biopsies revealed the underlying cause.
• The patient's presentation and the tumor's origin were highly unique.

Findings:

• The patient was diagnosed with malignant peritoneal mesothelioma (MPM).
• The primary tumor site was identified within the colon.
• This represents one of only four documented cases of MPM originating from the colon.

Implications:

• This case expands the understanding of rare MPM presentations and colon cancer associations.
• Highlights the importance of thorough diagnostic workups, including colonoscopy, for unexplained ascites.
• Contributes to the limited literature on colonic primary malignant peritoneal mesothelioma, aiding future research and clinical management.