Elevated high-sensitive troponin T in negative stress test individuals
Rafael Y Brzezinski1, Eyal Fisher2, Michal Ehrenwald1
1Department of Internal Medicine "C", "D" and "E", Tel Aviv Sourasky Medical Center and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
The exercise ECG stress test (EST) and high-sensitive cardiac troponin T (hs-cTnT) are common cardiovascular assessments. This study found no significant association between EST results and hs-cTnT detection in a large cohort.
Area of Science:
- Cardiology
- Clinical Diagnostics
- Biomarker Research
Background:
- Exercise ECG stress testing (EST) is a primary diagnostic tool for intermediate-risk patients.
- Elevated high-sensitive cardiac troponin T (hs-cTnT) predicts cardiovascular events.
- The relationship between EST and hs-cTnT is not well-established.
Purpose of the Study:
- To investigate the association between exercise ECG stress test (EST) results and high-sensitive cardiac troponin T (hs-cTnT) levels.
- To determine if hs-cTnT elevation is linked to abnormal EST findings in a general health survey population.
Main Methods:
- Analysis of 2780 participants from the Tel-Aviv Medical Center Inflammation Survey cohort.
- Collection of various physiological and metabolic parameters, including hs-cTnT.
- Manual review of exercise ECG stress tests (EST) by a cardiologist for all participants.
Main Results:
- A positive EST was observed in 8% of participants.
- The majority of participants with detectable hs-cTnT levels (5-14 ng/L and >14 ng/L) had negative EST results.
- No statistically significant difference in the proportion of positive EST with detectable hs-cTnT was found compared to negative EST.
Conclusions:
- In individuals undergoing EST for annual health surveys, there is no significant association between EST outcomes and hs-cTnT detection.
- These findings suggest that hs-cTnT may not be a reliable indicator of abnormal EST findings in this specific population.
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