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Related Concept Videos

Transdermal Drug Delivery Systems01:18

Transdermal Drug Delivery Systems

3
Transdermal drug delivery systems (TDDS) enable the controlled release of drugs across the skin into systemic circulation. They are particularly advantageous for drugs with short half-lives or narrow therapeutic indices, as they maintain consistent plasma concentrations and reduce the risk of subtherapeutic or toxic levels.TDDS are categorized into monolithic, reservoir, and mixed systems. Monolithic systems embed the drug in a polymer matrix, where diffusion governs release. Reservoir systems...
3
Ophthalmic Drug Delivery Systems01:23

Ophthalmic Drug Delivery Systems

1
Ophthalmic drug delivery faces major limitations due to poor absorption across the corneal membrane. This process is primarily driven by diffusion and is influenced by two main factors: the physicochemical properties of the drug and tear drainage. Most ophthalmic drugs, such as pilocarpine, epinephrine, atropine, and local anesthetics, are weak bases. They are typically formulated at an acidic pH to enhance chemical stability. However, this leads to high ionization, reducing their ability to...
1
Drug Delivery Systems: Different Types01:27

Drug Delivery Systems: Different Types

1
Conventional oral drug products, termed immediate-release (IR) formulations, are engineered to promptly release their active pharmaceutical ingredient (API) upon ingestion, typically in tablets or capsules. This rapid release often results in swift drug absorption and consequent pharmacodynamic effects, although the timing and intensity can vary depending on the drug's properties. Prodrugs within these formulations require metabolic conversion to activate their pharmacodynamic effects,...
1
Intrauterine Drug Delivery Systems01:21

Intrauterine Drug Delivery Systems

1
Controlled-release systems for intravaginal and intrauterine drug delivery have been developed primarily for the administration of contraceptive steroid hormones. These delivery routes circumvent first-pass hepatic metabolism, thereby enhancing bioavailability and allowing for reduced systemic dosages compared to oral administration. Such approaches contribute to improved therapeutic efficacy and patient compliance, particularly in long-term contraceptive regimens.Intravaginal Drug Delivery...
1
Oral Drug Delivery Systems: Continuous-Release Systems01:26

Oral Drug Delivery Systems: Continuous-Release Systems

1
Continuous-release drug delivery systems offer a strategic approach to maintaining therapeutic drug levels over extended periods following oral administration. By modulating the release rate of active pharmaceutical ingredients, these systems minimize fluctuations in plasma concentrations, which enhances clinical efficacy and reduces the need for frequent dosing. Such characteristics make them particularly advantageous in managing chronic diseases where patient adherence and stable drug...
1
Oral Drug Delivery Systems: Delayed-Release Systems01:11

Oral Drug Delivery Systems: Delayed-Release Systems

2
Delayed-release drug delivery systems are specialized pharmaceutical formulations designed to postpone the release of active compounds until the drug reaches a specific region of the gastrointestinal (GI) tract, typically the intestine. These systems are essential for drugs that may cause gastric irritation, are unstable in acidic environments, or need to exert therapeutic effects locally in the intestinal or colonic regions.The core feature of delayed-release systems is the use of enteric...
2

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Models and Methods to Evaluate Transport of Drug Delivery Systems Across Cellular Barriers
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Neutrophil-Based Drug Delivery Systems.

Dafeng Chu1, Xinyue Dong1, Xutong Shi1

  • 1Department of Pharmaceutical Sciences, College of Pharmacy, Washington State University, Spokane, WA, 99210, USA.

Advanced Materials (Deerfield Beach, Fla.)
|March 27, 2018
PubMed
Summary

This review explores neutrophil-based drug delivery systems, utilizing neutrophils or their derived nanovesicles. These systems show promise for targeted delivery in treating inflammation and cancers.

Keywords:
cancerinflammationnanovesiclesneutrophilstargeted drug delivery

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Area of Science:

  • Immunology
  • Nanotechnology
  • Drug Delivery

Background:

  • White blood cells (WBCs), particularly neutrophils, are crucial for immunity and acute inflammation.
  • Neutrophil adhesion and infiltration are key in inflammatory processes, relevant to autoimmune disorders, and cancer therapies.
  • Targeting activated neutrophils presents a novel strategy for developing advanced drug delivery systems.

Purpose of the Study:

  • To review a new drug delivery platform based on neutrophils.
  • To discuss two types of neutrophil-based drug delivery systems: neutrophils as carriers and neutrophil-membrane-derived nanovesicles.
  • To highlight the potential of these systems in treating inflammatory diseases and cancers.

Main Methods:

  • Review of existing literature on neutrophil-based drug delivery.
  • Discussion of mechanisms for nanoparticle hijacking of neutrophils in vivo.
  • Analysis of neutrophil-membrane-derived nanovesicles for targeting inflamed vasculature.

Main Results:

  • Neutrophils can be exploited as carriers for targeted drug delivery.
  • Nanoparticles can hijack neutrophils to cross blood vessel barriers.
  • Neutrophil-membrane-derived nanovesicles effectively target inflamed vasculature.

Conclusions:

  • Neutrophil-based drug delivery platforms offer a promising approach for targeted therapeutics.
  • These systems have significant potential in managing inflammatory conditions and combating cancer.
  • Further development of neutrophil-based strategies could revolutionize targeted medicine.