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Updated: Feb 12, 2026
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A Quick Phenotypic Neurological Scoring System for Evaluating Disease Progression in the SOD1-G93A Mouse Model of ALS
Published on: October 6, 2015
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Mouse models of ALS: Past, present and future
1The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine 04609, USA.
Brain Research
|March 27, 2018
Summary
Recent gene discoveries in Amyotrophic Lateral Sclerosis (ALS) are driving the development of new mouse models. These models, utilizing advanced genetic engineering, will improve our understanding and therapeutic strategies for ALS.
Area of Science:
- Neuroscience
- Genetics
- Disease Modeling
Background:
- Genome sequencing has rapidly identified numerous genes implicated in Amyotrophic Lateral Sclerosis (ALS).
- Understanding these genetic factors is crucial for elucidating disease mechanisms and developing targeted therapies.
- Mouse models are vital for studying ALS pathophysiology and preclinical therapeutic testing.
Purpose of the Study:
- To review the evolution of mouse models for Amyotrophic Lateral Sclerosis (ALS).
- To discuss the impact of recent genetic discoveries on ALS research.
- To explore future opportunities for developing and utilizing advanced mouse models.
Main Methods:
- Review of existing literature on ALS genetics and mouse models.
- Discussion of genetic engineering technologies like CRISPR/Cas9.
- Highlighting the utility of diverse genetic resources such as the Collaborative Cross and Diversity Outbred panels.
Main Results:
- Accelerated identification of ALS-associated genes.
- Advancements in mouse genetic engineering enabling precise mutation introduction.
- Emergence of new mouse models reflecting diverse genetic backgrounds and population contexts.
Conclusions:
- New genetic discoveries in ALS necessitate the development of sophisticated mouse models.
- Advanced genetic technologies and diverse mouse populations offer unprecedented opportunities for ALS research.
- Future mouse models will be critical for advancing our understanding and treatment of ALS.
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