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Adrenomedullin: Continuing to explore cardioprotection.

Toshihiro Tsuruda¹, Johji Kato², Kenji Kuwasako²

¹Department of Internal Medicine, Circulatory and Body Fluid Regulation, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889-1692, Japan.

|March 27, 2018

Summary

Adrenomedullin (AM) is a peptide that plays a crucial role in cardiovascular health, particularly in regulating vascular tone and protecting the heart. Research explores its therapeutic potential for heart failure and other cardiac conditions.

Keywords:

Contractility Embryogenesis Heart failure Hypertrophy Remodeling

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Area of Science:

Cardiovascular Biology
Endocrinology
Molecular Medicine

Background:

Adrenomedullin (AM) is a 52-amino acid peptide found in human tissues, including the heart.
AM levels elevate in conditions like cardiac hypertrophy, myocardial infarction, and heart failure.
Its primary role involves regulating vascular tone through vasodilation and natriuresis.

Purpose of the Study:

To review the pathophysiological roles of AM and its receptor system in the heart.
To discuss AM's cardioprotective properties, including inhibition of aldosterone secretion, oxidative stress, and apoptosis.
To explore AM and proAM-derived peptides as diagnostic biomarkers and therapeutic agents for cardioprotection.

Main Methods:

Review of existing literature on Adrenomedullin (AM) and its role in cardiovascular physiology and pathology.
Analysis of the Adrenomedullin (AM) receptor complex, comprising calcitonin receptor-like receptor (CLR) and receptor activity-modifying proteins (RAMP) 2 or 3.
Examination of clinical trial data on recombinant AM peptide therapy for heart failure.

Main Results:

The AM-CLR/RAMP2 system is vital for heart development.
AM exhibits cardioprotective effects by inhibiting aldosterone, oxidative stress, and apoptosis, and stimulating angiogenesis.
Clinical trials indicate the efficacy and safety of recombinant AM peptide therapy for heart failure.

Conclusions:

Adrenomedullin (AM) is a key peptide in cardiovascular regulation and protection.
Modified AM peptides and gene delivery offer innovative therapeutic strategies for heart conditions.
AM and its derivatives show promise as both diagnostic biomarkers and therapeutic agents for cardioprotection.