Related Experiment Video

Updated: Feb 12, 2026

Mouse Kidney Transplantation: Models of Allograft Rejection
16:15

Mouse Kidney Transplantation: Models of Allograft Rejection

Published on: October 11, 2014

21.7K

Correlations between donor-specific antibodies and non-adherence with chronic active antibody-mediated rejection

Jorge Malheiro1, Sofia Santos2, Sandra Tafulo3

  • 1Nephrology and Kidney Transplantation Department, Hospital de Santo António, Centro Hospitalar do Porto, Portugal; Unit for Multidisciplinary Investigation in Biomedicine (UMIB), Porto, Portugal.

Human Immunology
|March 27, 2018
PubMed

Insights

Chronic-active antibody-mediated rejection (CAABMR) in kidney transplants is worsened by donor-specific antibodies (DSA), leading to poorer graft survival. Identifying DSA and non-adherence is crucial for predicting outcomes.

Area of Science:

  • Nephrology
  • Immunology
  • Transplantation Science

Background:

  • Chronic-active antibody-mediated rejection (CAABMR) significantly reduces kidney graft survival.
  • Effective treatments for CAABMR remain limited.
  • The impact of donor-specific antibodies (DSA) and immunosuppression adherence on CAABMR is not fully understood.

Purpose of the Study:

  • To investigate the influence of concurrent DSA and non-adherence on CAABMR histopathological features.
  • To evaluate the prognostic significance of DSA characteristics and non-adherence in CAABMR.
  • To identify predictors of graft failure in CAABMR patients.

Main Methods:

  • Analysis of 41 CAABMR cases using indication graft biopsies and Banff classification.
  • Assessment of concurrent DSA presence, characteristics (including C1q binding), and patient adherence to immunosuppression.
  • Statistical analysis to determine the impact of DSA and non-adherence on histopathology and graft survival.

Main Results:

  • 59% of CAABMR cases had detectable DSA.
  • DSA-positive patients showed significantly higher tubulointerstitial and acute humoral inflammation scores.
  • DSA-positive patients who were also non-adherent exhibited increased microvascular inflammation.
  • DSA positivity, non-adherence, and C1q positivity independently predicted graft failure.

Conclusions:

  • CAABMR with concurrent DSA significantly increases the risk of kidney graft failure.
  • Evaluating patient adherence and characterizing DSA are critical for risk stratification.
  • Histopathological phenotyping and DSA analysis provide vital prognostic information in CAABMR.

Keywords:
Chronic active antibody-mediated rejectionDonor-specific antibodiesKidney transplantationTransplant glomerulopathyTreatment

More Related Videos

A Method to Assess Fc-mediated Effector Functions Induced by Influenza Hemagglutinin Specific Antibodies04:47

A Method to Assess Fc-mediated Effector Functions Induced by Influenza Hemagglutinin Specific Antibodies

Published on: February 23, 2018

8.2K
Generation of Discriminative Human Monoclonal Antibodies from Rare Antigen-specific B Cells Circulating in Blood13:14

Generation of Discriminative Human Monoclonal Antibodies from Rare Antigen-specific B Cells Circulating in Blood

Published on: February 6, 2018

11.0K

Related Concept Videos

Antibody Structure01:10

Antibody Structure

Overview
Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
The Y-Shaped Structure of Antibodies Consists of Four Polypeptide Chains
Antibodies consist of four polypeptide chains: two identical heavy...
65.7K
Antibody Actions01:26

Antibody Actions

Antibodies, or immunoglobulins, are critical players in the immune system's arsenal against invading pathogens. Produced by B cells and plasma cells, their primary role is to detect and bind to specific antigens, molecules found on the surface of pathogens like bacteria or viruses. Beyond antigen recognition, antibodies perform several vital functions that contribute to immune defense.
Neutralization
Antibodies can bind to pathogens, preventing them from infecting host cells. This process...
2.9K
Antibody Structure and Classes01:25

Antibody Structure and Classes

Antibodies, also known as immunoglobulins, are produced by B cells in response to foreign substances, such as bacteria and viruses. These proteins are critical for recognizing and neutralizing these substances, protecting the body from potential harm.
The basic structure of an antibody consists of four protein chains: two identical heavy chains and two identical light chains. These chains are held together by disulfide bonds and other non-covalent interactions, forming a Y-shaped structure.
9.4K
Chronic Kidney Disease I: Introduction01:25

Chronic Kidney Disease I: Introduction

Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
766
Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
683
Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
485