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A Sensitive Visual Method for the Detection of Hydrogen Sulfide Producing Bacteria
Published on: June 27, 2022
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Hydrogen Sulfide Regulating Myocardial Structure and Function by Targeting Cardiomyocyte Autophagy
Qing-You Zhang1, Hong-Fang Jin1, Selena Chen2
1Department of Pediatrics, Peking University First Hospital, Beijing 100034, China.
Chinese Medical Journal
|March 27, 2018
Summary
Hydrogen sulfide (H2S) acts as a cardiovascular protector by modulating autophagy. This gas molecule targets cardiomyocyte autophagy, offering potential therapeutic strategies for heart diseases.
Area of Science:
- Cardiovascular Science
- Molecular Biology
- Cellular Biology
Background:
- Hydrogen sulfide (H2S) is a signaling molecule vital in cardiovascular pathophysiology.
- Autophagy is implicated in various cardiac diseases.
- H2S influences myocardial structure and function by altering autophagy, acting as a key regulator in myocardial diseases.
Purpose of the Study:
- To review the role of H2S in regulating cardiomyocyte autophagy.
- To summarize experimental evidence linking H2S, autophagy, and cardiovascular function.
Main Methods:
- Literature review of PubMed articles up to October 30, 2017.
- Selection of original articles and critical reviews on H2S and autophagy in cardiovascular diseases.
Main Results:
- H2S restores adaptive autophagy and downregulates detrimental autophagy, conferring cardioprotection.
- H2S demonstrates beneficial effects in myocardial ischemia/reperfusion by regulating autophagy.
- H2S inhibits autophagy during cardioplegia and cardiopulmonary bypass, offering protection.
- H2S delays cardiac aging and improves left ventricular function in smoking rats by modulating autophagy.
Conclusions:
- H2S provides cardiovascular protection through autophagy regulation.
- Cardiovascular autophagy presents a potential therapeutic target for H2S-based treatments in cardiovascular diseases.
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