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Muscle function in haemophilia patients declines over time, even without obvious joint damage. Surface electromyography (sEMG) effectively detects this muscle dysfunction, aiding early rehabilitation for haemophilia.

Keywords:
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Area of Science:

  • Orthopedics
  • Neurology
  • Rehabilitation Medicine

Background:

  • Recurrent joint bleeds in haemophilia lead to chronic joint damage.
  • Muscle dysfunction, characterized by altered contraction patterns, often precedes structural joint damage.
  • Muscle function in haemophilia patients remains under-investigated.

Purpose of the Study:

  • To prospectively assess changes in lower limb muscle function over two years in haemophilia patients.
  • To evaluate the utility of surface electromyography (sEMG) in detecting muscle function alterations.

Main Methods:

  • A 2-year prospective study involving 60 severe haemophilia patients (ages 2-43).
  • Lower limb muscle function assessed using surface electromyography (sEMG) at baseline and follow-up.
  • Clinical assessment included the Haemophilia Joint Health Score (HJHS).

Main Results:

  • sEMG parameters were altered in all patients, regardless of target joints or HJHS.
  • Muscle function deterioration was observed after two years, despite stable HJHS scores.
  • No correlation found between sEMG alterations and target joints or abnormal HJHS.

Conclusions:

  • Lower limb muscle function is impaired in haemophilia patients, independent of overt joint damage.
  • sEMG is a sensitive tool for detecting muscle dysfunction in haemophilia.
  • Early detection of muscle dysfunction facilitates timely rehabilitation interventions.