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Updated: Aug 9, 2026

Mouse Kidney Transplantation: Models of Allograft Rejection
Published on: October 11, 2014
Correlation between high-molecular-weight Fc gamma-receptor-blocking factors in serum and renal allograft survival
Abstract:
In this study, we have demonstrated the occurrence of IgG class noncytotoxic, lymphocyte Fc gamma-receptor-blocking antibodies in a proportion of sera obtained from transfused uremic patients. The presence of these antibodies was not found to correlate with subsequent renal allograft survival. Serum fractionation studies did however reveal a striking correlation between graft survival and Fc gamma-receptor blocking mediated by a serum factor(s) with a sedimentation coefficient of greater than 19S. The precise nature of this factor remains to be clarified.
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