Related Experiment Video

Updated: Feb 12, 2026

Non-Invasive Ultrasound Assessment of Endometrial Cancer Progression in Pax8-Directed Deletion of the Tumor Suppressors Arid1a and Pten in Mice
07:44

Non-Invasive Ultrasound Assessment of Endometrial Cancer Progression in Pax8-Directed Deletion of the Tumor Suppressors Arid1a and Pten in Mice

Published on: February 17, 2023

2.1K

The Capicua tumor suppressor: a gatekeeper of Ras signaling in development and cancer

Lucía Simón-Carrasco1, Gerardo Jiménez2,3, Mariano Barbacid1

  • 1a Molecular Oncology Programme, Centro Nacional de Investigaciones Oncológicas (CNIO) , Melchor Fernández Almagro 3, Madrid , Spain.

Cell Cycle (Georgetown, Tex.)
|March 27, 2018
PubMed

Insights

The transcriptional repressor Capicua (CIC) regulates cell growth via RAS/MAPK signaling. This review highlights CIC's conserved roles in development, homeostasis, tumor suppression, and therapy resistance, impacting cancer treatment.

Area of Science:

  • Molecular Biology
  • Cellular Biology
  • Developmental Biology

Background:

  • Capicua (CIC) is a transcriptional repressor regulating cell growth.
  • CIC is negatively regulated by RAS/MAPK signaling, a pathway crucial in development and cancer.
  • CIC's function is conserved from Drosophila to mammals.

Purpose of the Study:

  • To review the multifaceted roles of CIC in mammalian systems.
  • To explore CIC's involvement in development, tissue homeostasis, and disease.
  • To discuss CIC's impact on tumor formation and therapeutic responses.

Main Methods:

  • Literature review of studies on Capicua (CIC) function.
  • Analysis of data from mammalian models and human studies.
  • Synthesis of information on CIC's regulatory mechanisms and biological impact.

Main Results:

  • CIC is implicated in diverse processes: lung development, liver homeostasis, autoimmunity, and neurobehavior.
  • CIC acts as a tumor suppressor in both human and mouse models.
  • CIC influences sensitivity to EGFR and MAPK pathway inhibitors.

Conclusions:

  • CIC is a critical regulator with broad biological significance.
  • CIC's role extends to cancer development and therapy resistance.
  • Understanding CIC regulation offers potential for novel cancer therapies.
Keywords:
CICEtv4Ras signalingT-ALLmouse models

More Related Videos

Method for Novel Anti-Cancer Drug Development using Tumor Explants of Surgical Specimens09:26

Method for Novel Anti-Cancer Drug Development using Tumor Explants of Surgical Specimens

Published on: July 29, 2011

17.1K
Monitoring Hippo Signaling Pathway Activity Using a Luciferase-based Large Tumor Suppressor LATS Biosensor07:16

Monitoring Hippo Signaling Pathway Activity Using a Luciferase-based Large Tumor Suppressor LATS Biosensor

Published on: September 13, 2018

20.7K

Related Concept Videos

Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
9.9K
Loss of Tumor Suppressor Gene Functions01:12

Loss of Tumor Suppressor Gene Functions

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
When the tumor suppressor genes develop mutations or are lost, cells start growing out of control, leading to cancer. However, a single functional copy of the tumor suppressor gene is enough for the cells to maintain their normal functions and cell...
6.1K
The Ras Gene02:38

The Ras Gene

The Ras-gene-encoded proteins are regulators of signaling pathways controlling cell proliferation, differentiation, or cell survival. The Ras-gene family in humans constitutes three primary members—the HRas, NRas, and KRas. These genes code for four functionally distinct yet closely related proteins—the HRas, NRas, KRas4A, and KRas4B. The involvement of mutant Ras genes in human cancer was first discovered in 1982 and is among the most common causes of human tumorigenesis.
Ras is a...
7.4K
Small GTPases - Ras and Rho01:24

Small GTPases - Ras and Rho

Ras and Rho are small monomeric GTPases that act downstream of receptor tyrosine kinase (RTK) and regulate various cellular processes. These GTPases switch between active and inactive states by binding to guanine nucleotides.
Three regulatory proteins control their activity:
5.5K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
4.9K
Cancer Stem Cells and Tumor Maintenance02:40

Cancer Stem Cells and Tumor Maintenance

Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
6.0K