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Updated: Feb 12, 2026

Alternative In Vitro Methods for the Determination of Viral Capsid Structural Integrity
Published on: November 16, 2017
Smectic viral capsids and the aneurysm instability
S Dharmavaram1, J Rudnick1, C M Lawrence2,3
1Department of Physics and Astronomy, University of California, Los Angeles, CA 90095, United States of America.
None:
The capsids of certain Archaea-infecting viruses undergo large shape changes, while maintaining their integrity against rupture by osmotic pressure. We propose that these capsids are in a smectic liquid crystalline state, with the capsid proteins assembling along spirals. We show that smectic capsids are intrinsically stabilized against the formation of localized bulges with non-zero Gauss curvature while still allowing for large-scale cooperative shape transformation that involves global changes in the Gauss curvature.
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