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Orthostatic Hypotension and Cognitive Function: Cross-sectional Results From the ELSA-Brasil Study
Claudia K Suemoto1,2, Cristina P Baena1,3, Jose G Mill4
1Center for Clinical and Epidemiological Research, University of São Paulo, Brazil.
Summary
Orthostatic hypotension (OH) and orthostatic hypertension are linked to worse verbal fluency in Brazilian adults. This study highlights the association in a diverse population, suggesting broader implications for cognitive health.
Area of Science:
- Neurology
- Cardiology
- Public Health
Background:
- Orthostatic hypotension (OH) association with cognitive impairment is debated, with limited research in non-Western, diverse populations.
- Most studies focus on older white adults, necessitating broader investigation.
Purpose of the Study:
- To examine the relationship between OH and cognitive performance in a large, racially diverse Brazilian adult cohort.
- To explore associations with verbal fluency, memory, and global cognition.
Main Methods:
- Cross-sectional analysis of 12,826 adults from the ELSA-Brasil study.
- OH defined by blood pressure drop (≥20/10 mmHg) upon standing.
- Multiple linear regression models assessed cognitive z-scores (global, memory, verbal fluency, TMT).
Main Results:
- Participants with OH (4%) showed significantly poorer verbal fluency (VF) scores.
- Orthostatic hypertension also correlated with worse VF performance.
- A borderline significant interaction suggested impaired cognition in those lacking heart rate compensation.
Conclusions:
- Orthostatic hypotension and orthostatic hypertension are associated with reduced verbal fluency in Brazilian adults.
- Findings emphasize the importance of postural blood pressure changes in cognitive health across diverse populations.
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